Co-delivery of chemotherapeutic drugs and cell cycle regulatory agents using nanocarriers for cancer therapy

Combination chemotherapy is widely exploited to overcome multidrug resistance (MDR) and enhance the therapeutic effect of anti-tumor agents clinically. The traditional combination regimens applied in clinical practice still suffer from various obstacles, such as inevitable side effects. Fortunately, application nanotechnology proposal co-delivery systems make therapy more effective. occurrence, development, metastasis tumors are closely related cell cycle. sensitivity tumor cells chemotherapeutic drugs can be improved with cooperation cycle regulators. In this review, influence on tumorigenesis development introduced briefly. current strategies combining regulators through discussed detail. We also sketch possibility treating mildly via artificially controlling outline challenges perspectives about improvement for cancer therapy.